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March 17, 2011 4:40 p.m.

Plaque-blocking compound may aid Alzheimer's treatment »

Kim Green
Researchers with the Institute for Memory Impairments and Neurological Disorders (UCI MIND) have discovered how a novel compound can reduce the accumulation of brain plaques seen in Alzheimer's without the side effects produced by current drugs used for the chronic neurodegenerative disease. In a study published online in the Annals of Neurology, neurobiologists Kim Green and Frank LaFerla found that the ST101 compound triggers a process that carves up amyloid precursor proteins into benign molecules. These precursor proteins, when intact, ultimately can form into beta-amyloid plaques, which are the hallmark lesions of Alzheimer's and believed to be the primary cause of dementia. The researchers believe ST101 could be the basis of a drug therapy for people with mild Alzheimer's symptoms.

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Related topics: Research, Alzheimer's, UCI MIND, Neuroscience, Health & Medicine, Faculty, Medicine, Biological Sciences, Brain & Memory
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